Avanafil, like other PDE5 inhibitors, inhibits the action of the phosphodiesterase type 5 enzyme. This inhibition increases the levels of cyclic guanosine monophosphate (cGMP), a molecule that promotes relaxation of the smooth muscles in the blood vessels of the ****. This relaxation allows increased blood flow to the ****, leading to an erection when ****ual stimulation occurs.
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